A huge fire has engulfed a tower block in Latimer Road, west London, with eyewitnesses claiming people are trapped in their homes.
The fire at Grenfell Tower on the Lancaster West Estate was reported at 01:16 BST and about 200 firefighters are tackling the blaze.
The Met Police said people were being treated for "a range of injuries".
The BBC's Andy Moore said the whole tower block was alight and there are fears the building might collapse.
London Fire Brigade sent 40 fire engines to the tower, and Mayor of London Sadiq Khan said a "major incident" had been declared.
The Hammersmith and City and Circle lines have been closed between Edgware Road and Hammersmith because of the fire.
Eyewitnesses said they could see lights - thought to be torches - flashing at the top of the block of flats, which people say is "close to burning through".
Sophia, who is about 500m away from the building, said: "There are lots of people gathered in the street. I just see more and more flames burning and tragically I hear people crying for help.